A Study of the Change in Early and Sustained Pain Control in Axial Spondylarthritis in Adult Participants Receiving Upadacitinib

Brief summary

Axial spondyloarthritis (axSpA) is an immune-mediated inflammatory disease primarily affecting the axial skeleton. The most frequent axSpA symptom is chronic, often inflammatory back pain (IBP) that might be difficult to distinguish from other causes of chronic back pain (CBP). Many participants report persistent pain, including back pain, which impacts disease activity and quality of life including creating burdens such as sleep disturbance, social isolation, loss of productivity, as well as anxiety and depression. This study will assess the real-world effectiveness of upadacitinib on early and sustained pain control, and the association between pain and clinical/patient-reported outcomes in axSpA participants. Upadacitinib is being developed for the treatment of axSpA. Approximately 650 adult participants with active-axSpA will be enrolled across approximately 19 countries in Europe, North America, South America, and Asia-Pacific. Participants will receive oral upadacitinib tablets as prescribed by the physician prior to enrolling in this study in accordance with the terms of the local marketing authorization and professional and reimbursement guidelines with regards to dose, population and indication. Participants will be followed for 12 months. There may be a higher burden for participants in this study compared to usual standard of care. Participants will attend regular visits per routine clinical practice. The effect of the treatment will be checked by medical assessments, checking for side effects, and questionnaires.

Observational study

Active, not recruiting
Axial Spondylarthritis (axSpA)
650 patients
Protocol ID:
Observational model:
Time perspective:


Eligibility criteria

Participant attributes:
Male and Female


18 Years and older.

Inclusion Criteria:

- Clinical diagnosis of Axial Spondylarthritis (axSpA) according to the ASAS criteria.

- Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score >= 4 at Baseline.

- Total back pain score >= 4 at Baseline.

- Inadequate response to at least two nonsteroidal anti-inflammatory drugs (NSAIDs) over
an at least 4-week period in total at maximum recommended or tolerated doses, or
participant has an intolerance to contraindication for NSAIDs as defined by the

- Upadacitinib prescribed in accordance with the applicable approved label and local
regulatory and reimbursement policies.

Exclusion Criteria:

- Prior exposure to any Janus kinase (JAK) inhibitor.

- Participants demonstrating active symptoms of fibromyalgia as per clinical diagnosis.

- Participation in a clinical trial of an investigational drug, concurrently or within
the last 30 days.

- Unwillingness or inability to comply with the study requirements, including completion
of patient reported outcome questionnaires.

- Participants who cannot be treated with upadacitinib according to the applicable
approved label (e.g., contraindications).

- Vulnerable or protected adult patients with lack of capability to give informed

All the cities where the clinical studies are located

Vancouver - V5Z 1J9
Sydney - B1S 3N1
Dundas - L9H 1B7
Etobicoke - M9C 5N2
Hamilton - L8N 1Y2
Mississauga - L5M 2V8
Orillia - L3V 1T5
Windsor - N8X 1T3
Montreal - H1T 2M4
Montréal - H4A 3T2
Sainte-foy - G1V 3M7
Sherbrooke - J1G 2E8
Saskatoon - S7H 5M7
Winnipeg - R3A 1M3
Winnipeg - R3N 0K6

More information about this study