NCT03821935

Inclusion Criteria:

- For Dose Escalation only: Participants with an advanced solid tumor who are
considered refractory to or intolerant of all existing therapy(ies) known to provide
a clinical benefit for their condition. Additionally, participants who have been
offered standard therapies and refused, or who are considered ineligible for
standard therapies, may be eligible for this study on a case-by-case basis, after
discussion with and agreement from the sponsor. Participants with pancreatic
adenocarcinoma, urothelial cancer (UC), hepatocellular carcinoma (HCC), or head and
neck squamous cell carcinoma (HNSCC) who are being considered for the dose
escalation cohorts must also meet the histology specific eligibility criteria
described below for dose expansion.

- For Dose Expansion only participants must meet criteria specific to the type of
cancer:

- Pancreatic adenocarcinoma and have disease progression during or after 1
systemic therapy (gemcitabine monotherapy or in combination with other agents,
FOLFIRINOX [or another regimen including both 5-fluorouracil and oxaliplatin],
capecitabine monotherapy or in combination with other agents) administered in
the adjuvant, locally advanced, or metastatic setting. If the therapy was used
in an adjuvant setting, disease progression must have occurred within 6 months
of completing adjuvant therapy.

- UC of the bladder and urinary tract and must have progressed following
treatment with:

- Cohort 4: A platinum-based regimen (administered in any line of therapy) and a
programmed death 1/programmed death ligand 1 (PD1/PDL1) antagonist administered
in the recurrent or metastatic setting (progression following a PD1/PDL1
antagonist is defined as unequivocal progression on or within 3 months of the
last dose of anti-PD1 or anti-PDL1 therapy).

- Cohort 11: One or more prior line of therapy in the locally advanced or
metastatic setting. Participant must have experienced radiographic progression
or relapse during or after a CPI (anti-PD1 or anti-PD-L1) for locally advanced
or metastatic disease.

- HCC and must have disease progression during or after 1 prior line of systemic
therapy.

- HNSCC (arising from the oral cavity, oropharynx, hypopharynx, or larynx) and
must have progressed following treatment with platinum-based regimen
(administered in any line of therapy) and a PD1/PDL1 antagonist administered in
the recurrent or metastatic setting (progression following a PD1/PDL1
antagonist is defined as unequivocal progression on or within 3 months of the
last dose of anti-PD1 or anti-PDL1 therapy).

- Microsatellite stable colorectal cancer (MSS-CRC) [unselected] participants
with microsatellite stable or mismatch repair proficient colorectal
adenocarcinoma (as determined by polymerase chain reaction
(PCR)/Next-Generation sequencing (NGS) or immunohistochemistry (IHC),
respectively) who have received 1-2 prior chemotherapy regimens.

- Non-small cell lung cancer (NSCLC) relapsed/refractory (R/R): Participants with
histologically or cytologically confirmed advanced or metastatic NSCLC who have
received 1 prior line of chemotherapy and 1 prior anti-PD-(L)1 antibody,
administered either concurrently or sequentially in the metastatic setting.

- MSS-CRC (CMS4 enriched): Participants with microsatellite stable or mismatch
repair proficient colorectal adenocarcinoma who have received prior
fluorouracil-based combination chemotherapy regimens including oxaliplatin and
irinotecan (with or without VEGF and/or EGFR targeted agents) and with a CMS4
subtype as determined by NGS of tumor biopsies. Archival tissue must be
submitted for assessment of CMS4 subtype status during prescreening.
Participants must have progressed on or refused available standard of care
therapies. Additionally, participant who are considered not appropriate or
ineligible for available standard of care therapies per investigator assessment
will be eligible for this study.

- Ovarian granulosa (OG) cell tumor: Participants with histologically confirmed
advanced nonresectable or metastatic adult granulosa cell tumor of the ovary
that is not amenable to curative intent surgery or radiation. Additionally,
there is documentation of radiological evidence of relapse after at least 1
line of systemic chemotherapy.

- Participant has an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0
to 1.

- Participant has adequate bone marrow, renal, hepatic, and coagulation function.

- Must have a viral status consistent with the requirements described in the protocol
specific to type of cancer and stage of study (Dose Escalation or Dose Expansion).

Exclusion Criteria:

- For Dose Expansion only:

- Participants with HCC, pancreatic adenocarcinoma, or MSS-CRC having prior
exposure to a prior PD-1/PD-L1 antagonist in any line of therapy.

- Participants (except for participants with urothelial cancer or HNSCC) who have
had prior exposure to immunotherapies as listed in the protocol.

- Has received anticancer therapy including chemotherapy, immunotherapy, radiation
therapy, biologic, herbal therapy, or any investigational therapy within a period of
5 half-lives or 28 days (whichever is shorter), prior to the first dose of the study
drug.

- Participant has unresolved AEs > Grade 1 from prior anticancer therapy except for
alopecia.

- Has a history of primary immunodeficiency, bone marrow transplantation, solid organ
transplantation, or previous clinical diagnosis of tuberculosis.

- Has a known uncontrolled metastases to the central nervous system (with certain
exceptions).

- Current or prior use of immunosuppressive medication within 14 days prior to the
first dose of the study drug.

- Has clinically significant uncontrolled condition(s).

- History of inflammatory bowel disease, interstitial lung disease or pneumonitis,
myocarditis, Stevens-Johnson syndrome, toxic epidermal necrolysis or drug reaction
with eosinophilia and systemic symptoms (DRESS).

- Live vaccine administration <= 28 days prior to the first dose of study drug.