NCT06365853

Inclusion Criteria:

- Participants must have a confirmed diagnosis of epithelial ovarian, fallopian tube,
and primary peritoneal cancer (EOC) with high FRα expression.

- Participant's tumor must be FRα positive (FRα high) as defined by either the Ventana
folate receptor 1 (FOLR1) (FOLR1-2.1) CDx Assay or FOLR1-2.1 RxDx Assay (hereafter
collectively termed: Ventana FOLR1 Assay) (≥75% cells exhibit 2 or 3+
membrane-staining intensity).

- Participants with known breast cancer susceptibility gene (BRCA) mutations (tumor or
germline) must have received poly (ADP-ribose) polymerase inhibitors (PARPi).

- Participants must have completed prior therapy within the specified times below:

1. Systemic antineoplastic therapy ≥ 5 half-lives or 4 weeks (whichever is
shorter) before first dose of MIRV;

2. Focal radiation completed ≥ 2 weeks before the first dose of MIRV.

- Participants must have stabilized or recovered (Grade 1 or baseline) from all prior
therapy-related toxicities (except alopecia).

- Women of childbearing potential (WOCBP) must agree to use highly effective
contraceptive method(s) while on MIRV and for ≥ 7 months after the last dose; and
must have a negative pregnancy test ≤ 4 days before the first dose of MIRV.

Exclusion Criteria:

- Participants with borderline ovarian tumor or non-epithelial histology or mixed
histology including borderline or non-epithelial histology will be excluded.

- PROC participants with primary platinum-refractory disease, defined as disease that
did not respond to (complete response [CR] or partial response [PR]) or progressed
within ≤ 3 months of the last dose of first line platinum-containing chemotherapy.

- Participants with > Grade 1 peripheral neuropathy per National Cancer
Institute-Common Terminology Criteria for Adverse Events version 5.0 (NCI-CTCAE
v5.0).

- Participants with significant active or chronic corneal disorders (for example,
corneal dystrophies, degenerations, limbal stem cell deficiency), history of corneal
transplantation, significant ocular inflammatory conditions (for example, active or
recurrent uveitis), or other active ocular conditions requiring ongoing
treatment/monitoring, such as uncontrolled glaucoma, active diabetic retinopathy
with macular edema, macular degeneration requiring treatment ≤ 90 days before first
dose, presence of papilledema, best corrected visual acuity (BCVA) worse than 20/70
in either eye, or monocular vision.

- Participants receiving corticosteroid or vasoconstricting eyedrops at baseline or
within 5 weeks of Cycle 1 Day 1.

- Participants who received prior treatment with MIRV or other FRα-targeting agents.
Note: Other protocol-defined inclusion and exclusion criteria may apply.