NCT05041257

Key Inclusion Criteria:

1. Patients ≥ 18 years of age

2. Patients must have an Eastern Cooperative Oncology Group Performance Status (ECOG
PS) of 0 or 1

3. Patients must have a confirmed diagnosis of high-grade serous EOC, primary
peritoneal cancer, or fallopian tube cancer

4. Patients must have platinum-sensitive disease defined as radiographic progression
greater than 6 months from last dose of most recent platinum therapy Note:
Progression should be calculated from the date of the last administered dose of
platinum therapy to the date of the radiographic imaging showing progression

5. Patients must have progressed radiographically on or after their most recent line of
anticancer therapy

6. Patients must have at least 1 lesion that meets the definition of measurable disease
by RECIST v1.1 (radiologically measured by the Investigator)

7. Patients must be willing to provide an archival tumor tissue block or slides, or
undergo procedure to obtain a new biopsy using a low-risk, medically routine
procedure for immunohistochemistry (IHC) confirmation of FRα positivity

8. Patient's tumor must be positive for FRα expression as defined by the Ventana FOLR1
Assay

9. Prior anticancer therapy

1. Patients must have received at least 2 prior systemic lines of platinum therapy
and be considered by the Investigator as appropriate for single-agent
non-platinum therapy (documentation required - eg, high risk of
hypersensitivity reaction; risk of further cumulative toxicity with additional
platinum, including but not limited to myelosuppression, neuropathy, renal
insufficiency or other) i. Note: Patients who have had a documented platinum
allergy may have had only 1 prior line of platinum

2. Patients may have received up to but no more than 1 prior independent
non-platinum cytotoxic therapy

3. Patients must have had testing for breast cancer susceptibility gene (BRCA)
mutation (tumor or germline) and, if positive, must have received a prior poly
(ADP-ribose) polymerase ( (PARP) inhibitor as either treatment or maintenance
therapy

4. Neoadjuvant ± adjuvant therapies are considered 1 line of therapy

5. Maintenance therapy (eg, bevacizumab, PARP inhibitors) will be considered part
of the preceding line of therapy (ie, not counted independently)

6. Therapy changed due to toxicity in the absence of progression will be
considered part of the same line (ie, not counted independently)

10. Patients must have completed prior therapy within the specified times below:

1. Systemic antineoplastic therapy within 5 half-lives or 4 weeks (whichever is
shorter) prior to first dose of MIRV

2. Focal radiation completed at least 2 weeks prior to first dose of MIRV

11. Patients must have stabilized or recovered (Grade 1 or baseline) from all prior
therapy-related toxicities (except alopecia)

12. Patients must have completed any major surgery at least 4 weeks prior to first dose
of MIRV and have recovered or stabilized from the side effects of prior surgery
prior to first dose of MIRV

13. Patients must have adequate hematologic, liver and kidney functions defined as:

1. Absolute neutrophil count (ANC) ≥ 1.5 x 10^9/L (1500/μL) without granulocyte
colony-stimulating factor (G-CSF) in the prior 10 days or long-acting white
blood cell (WBC) growth factors in the prior 20 days

2. Platelet count ≥ 100 x 10^9/L (100,000/μL) without platelet transfusion in the
prior 10 days

3. Hemoglobin ≥ 9.0 g/dL without packed red blood cell (PRBC) transfusion in the
prior 21 days

4. Serum creatinine ≤ 1.5 x upper limit of normal (ULN)

5. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3.0 x ULN

6. Serum bilirubin ≤ 1.5 x ULN (patients with documented diagnosis of Gilbert
syndrome are eligible if total bilirubin < 3.0 x ULN)

7. Serum albumin ≥ 2 g/dL

14. Patients must be willing and able to sign the informed consent form (ICF) and to
adhere to the protocol requirements

15. Women of childbearing potential (WCBP) must agree to use highly effective
contraceptive method(s) while on MIRV and for at least 3 months after the last dose

16. WCBP must have a negative pregnancy test within the 4 days prior to the first dose
of MIRV

Key Exclusion Criteria-

1. Patients with endometrioid, clear cell, mucinous, or sarcomatous histology, mixed
tumors containing any of the above histologies, or low-grade/borderline ovarian
tumor

2. Patients with prior wide-field radiotherapy (RT) affecting at least 20% of the bone
marrow

3. Patients with > Grade 1 peripheral neuropathy per Common Terminology Criteria for
Adverse Events (CTCAE)

4. Patients with active or chronic corneal disorders, history of corneal
transplantation, or active ocular conditions requiring ongoing treatment/monitoring,
such as uncontrolled glaucoma, wet age-related macular degeneration requiring
intravitreal injections, active diabetic retinopathy with macular edema, macular
degeneration, presence of papilledema, and/or monocular vision

5. Patients with serious concurrent illness or clinically relevant active infection,
including, but not limited to the following:

1. Active hepatitis B or C infection (whether or not on active antiviral therapy)

2. HIV infection

3. Active cytomegalovirus infection

4. Any other concurrent infectious disease requiring IV antibiotics within 2 weeks
prior to the first dose of MIRV

Note: Testing at screening is not required for the above infections unless
clinically indicated.

6. Patients with a history of multiple sclerosis (MS) or other demyelinating disease
and/or Lambert-Eaton syndrome (paraneoplastic syndrome)

7. Patients with clinically significant cardiac disease including, but not limited to,
any of the following:

1. Myocardial infarction ≤ 6 months prior to first dose

2. Unstable angina pectoris

3. Uncontrolled congestive heart failure (New York Heart Association > class II)

4. Uncontrolled ≥ Grade 3 hypertension (per CTCAE)

5. Uncontrolled cardiac arrhythmias

8. Patients with a history of hemorrhagic or ischemic stroke within 6 months prior to
enrollment

9. Patients with a history of cirrhotic liver disease (Child-Pugh Class B or C)

10. Patients with a previous clinical diagnosis of noninfectious interstitial lung
disease (ILD), including noninfectious pneumonitis

11. Patients requiring use of folate-containing supplements (eg, folate deficiency)

12. Patients with prior hypersensitivity to monoclonal antibodies (mAb)

13. Women who are pregnant or breastfeeding

14. Patients who received prior treatment with MIRV or other FRα-targeting agents

15. Patients with untreated or symptomatic central nervous system (CNS) metastases

16. Patients with a history of other malignancy within 3 years prior to enrollment

Note: patients with tumors with a negligible risk for metastasis or death (eg,
adequately controlled basal-cell carcinoma or squamous-cell carcinoma of the skin,
or carcinoma in situ of the cervix or breast) are eligible.

17. Prior known hypersensitivity reactions to study drugs and/or any of their excipients