AD Up
Brief summary
The objective of this study is to assess the efficacy and safety of an active drug combined with topical corticosteroids (TCS) for the treatment of adolescent and adult participants with moderate to severe Atopic dermatitis (AD) who are candidates for systemic therapy.
Interventional study
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Would you like to know more about this trial?
Yes, please contact meAge:
From 12 Years to 75 Years.
Inclusion Criteria:
- Body weight of >= 40kg at Baseline Visit for participants between >=12 and <18 years
of age
- Chronic atopic dermatitis (AD) with onset of symptoms at least 3 years prior to
Baseline Visit
- Active moderate to severe atopic dermatitis defined by Eczema Area and Severity Index
(EASI), Investigator's Global Assessment (IGA), Body surface area (BSA), and pruritus
- Candidate for systemic therapy or have recently required systemic therapy for atopic
dermatitis
- Documented history of inadequate response to topical corticosteroids or topical
calcineurin inhibitor OR documented systemic treatment for AD within 6 months prior to
Baseline Visit
Exclusion Criteria:
- Prior exposure to any Janus kinase (JAK) inhibitor
- Unable or unwilling to discontinue current atopic dermatitis (AD) treatments prior to
the study
- Requirement of prohibited medications during the study
- Other active skin diseases or skin infections requiring systemic treatment or would
interfere with appropriate assessment of atopic dermatitis lesions
- Female subject who is pregnant, breastfeeding, or considering pregnancy during the
study
